Article

A <i>trans</i> -complementation system for SARS-CoV-2

2021-01-19

Abstract excerpt

<h4>ABSTRACT</h4> The biosafety level-3 (BSL-3) requirement to culture severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is a bottleneck for research and countermeasure development. Here we report a trans -complementation system that produces single-round infectious SARS-CoV-2 that recapitulates authentic viral replication. We demonstrate that the single-round infectious SARS-CoV-2 can be used at BSL-...

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Literature Corpus work: f217e355-e5d8-583b-a725-e21cdc577231
DOI: 10.1101/2021.01.16.426970

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