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A <i>Trans</i>-Complementation System for SARS-CoV-2

2021-01-21

Abstract excerpt

The biosafety level-3 (BSL-3) requirement to culture severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is a bottleneck for research and countermeasure development. Here we report a <i>trans</i>-complementation system that produces single-round infectious SARS-CoV-2 that recapitulates authentic viral replication. We demonstrate that the single-round infectious SARS-CoV-2 can be used at BSL-2 laboratories...

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Identifiers and source

Literature Corpus work
d4952e31-3b51-55b6-bb71-12d9a74d81f3
DOI
10.2139/ssrn.3770930
Open publication

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A <i>Trans</i>-Complementation System for SARS-CoV-2DOI 10.2139/ssrn.3770930
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