Article
Poliovirus: generation and characterization of mutants.
Current protocols in microbiology - 1 Jan 2013
Burrill Cecily P, Strings Vanessa R, Schulte Michael B, Andino Raul
Abstract excerpt
Poliovirus (PV) is the prototypical picornavirus. It is a non-enveloped RNA virus with a small (~7.5-kb) genome of positive polarity. cDNA clones of several strains are available, and infectious virus can be produced by the transfection of in vitro-transcribed viral genomes into an appropriate host cell. The ease of genetic studies in poliovirus is a primary reason that it has long served as a model to study RNA...
Topics
- Genetics, Microbial
- Mutation
- Poliovirus
- Virology