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Article

Packaging defects in pestiviral NS4A can be compensated by mutations in NS2 and NS3.

Journal of virology - 28 Sept 2023

Fellenberg Jonas, Dubrau Danilo, Isken Olaf, Tautz Norbert

Abstract excerpt

The non-structural (NS) proteins of the Flaviviridae members play a dual role in genome replication and virion morphogenesis. For pestiviruses, like bovine viral diarrhea virus, the NS2-3 region and its processing by the NS2 autoprotease is of particular importance. While uncleaved NS2-3 in complex with NS4A is essential for virion assembly, it cannot replace free NS3/4A in the viral replicase. Furthermore,...

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Source

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Identifiers

PMID: 37695056
DOI: 10.1128/jvi.00572-23
PMCID: PMC10537661

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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