Article
p53 gene mutations in human urothelial carcinomas: analysis by immunohistochemistry and single-strand conformation polymorphism.
Modern pathology : an official journal of the United States and Canadian Academy of Pathology, Inc - 1 Feb 1995
Oyasu R, Nan L, Szumel R C, Kawamata H, Hirohashi S
Abstract excerpt
We examined 60 cases of human urothelial carcinomas (27 superficial and 33 deeply invasive) for the frequency of p53 gene mutations. Forty-two cases were analyzed by both the immunohistochemical and the single-strand conformation polymorphism (SSCP) methods, and the remaining 18 cases were assayed by SSCP alone. For the latter assay, exons 4 to 8 were amplified by polymerase chain reaction, and the amplified...
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