p53 gene mutations in human urothelial carcinomas: analysis by immunohistochemistry and single-strand conformation polymorphism.

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Article

p53 gene mutations in human urothelial carcinomas: analysis by immunohistochemistry and single-strand conformation polymorphism.

Modern pathology : an official journal of the United States and Canadian Academy of Pathology, Inc - 1 Feb 1995

Oyasu R, Nan L, Szumel R C, Kawamata H, Hirohashi S

Abstract excerpt

We examined 60 cases of human urothelial carcinomas (27 superficial and 33 deeply invasive) for the frequency of p53 gene mutations. Forty-two cases were analyzed by both the immunohistochemical and the single-strand conformation polymorphism (SSCP) methods, and the remaining 18 cases were assayed by SSCP alone. For the latter assay, exons 4 to 8 were amplified by polymerase chain reaction, and the amplified...

Topics

Adult
Aged
Aged, 80 and over
Base Sequence
Carcinoma
DNA Mutational Analysis
Female
Genes, p53
Humans
Immunoenzyme Techniques
Male

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Middle Aged

Molecular Sequence Data

Mutation

Point Mutation

Polymerase Chain Reaction

Polymorphism, Single-Stranded Conformational

Urinary Bladder Neoplasms

Source

Open in PubMed

Identifiers

PMID: 7777479

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 29 Aug 2026. Prepared record publication-7777479-2026-08-29.1. Manifest publication-graph-cohort-2026-08-29.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 29 Aug 2026.

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