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Article

Characterization of an essential Orc2p-associated factor that plays a role in DNA replication.

Molecular and cellular biology - 1 Apr 1996

Hardy C F

Abstract excerpt

The Saccharomyces cerevisiae Orc2 protein is a subunit of the origin recognition complex, ORC, which binds in a sequence-specific manner to yeast origins of DNA replication. With screens for orc2-1 synthetic lethal mutations and Orc2p two-hybrid interactors, a novel Orc2p-associated factor (Oaf1p) was identified. OAF1 is essential, its gene product is localized to the nucleus, and an oaf1 temperature-sensitive...

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Identifiers

PMID: 8657159
DOI: 10.1128/MCB.16.4.1832
PMCID: PMC231170

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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