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Article

Alanine scanning of poliovirus 2CATPase reveals new genetic evidence that capsid protein/2CATPase interactions are essential for morphogenesis.

Journal of virology - 1 Sept 2012

Wang Chunling, Jiang Ping, Sand Claire, Paul Aniko V, Wimmer Eckard

Abstract excerpt

Polypeptide 2C(ATPase) is one of the most thoroughly studied but least understood proteins in the life cycle of poliovirus. Within the protein, multiple functional domains important for uncoating, host cell membrane alterations, and RNA replication and encapsidation have previously been identified. In this study, charged to alanine-scanning mutagenesis was used to generate conditional-lethal mutations in...

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Identifiers

PMID: 22761387
DOI: 10.1128/JVI.00914-12
PMCID: PMC3446611

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