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Article

Efficient Rescue of Hepatitis C Virus RNA Replication by trans -Complementation with Nonstructural Protein 5A

20 Dec 2004

Abstract excerpt

Studies of Hepatitis C virus (HCV) RNA replication have become possible with the development of subgenomic replicons. This system allows the functional analysis of the essential components of the viral replication complex, which so far are poorly defined. In the present study we wanted to investigate whether lethal mutations in HCV nonstructural genes can be rescued by trans-complementation. Therefore, a series...

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Identifiers

PMID: 15613318
DOI: 10.1128/jvi.79.2.896-909.2005

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