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Article

An intragenic revertant of a poliovirus 2C mutant has an uncoating defect.

Journal of virology - 1 Mar 1990

Li J P, Baltimore D

Abstract excerpt

A revertant was isolated from a temperature-sensitive poliovirus 2C mutant, 2C-31, which is defective in viral RNA synthesis. This revertant, called 2C-31R1, grew well at 39 degrees C and was not defective in RNA synthesis. However, in contrast to its parental mutant, 2C-31R1 was cold sensitive and could hardly grow at all at 32 degrees C. Analysis of a single-cycle growth revealed that 2C-31R1 was defective in...

Topics

Base Sequence
Cloning, Molecular
DNA Transposable Elements
DNA, Viral
Defective Viruses
Deoxyribonuclease EcoRI
Genes, Viral
Genetic Complementation Test
HeLa Cells
Humans
Molecular Sequence Data

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Mutation

Plasmids

Poliovirus

Temperature

Source

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Identifiers

PMID: 2154595
DOI: 10.1128/JVI.64.3.1102-1107.1990
PMCID: PMC249223

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 29 Aug 2026. Prepared record publication-2154595-2026-08-29.1. Manifest publication-graph-cohort-2026-08-29.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 29 Aug 2026.

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An intragenic revertant of a poliovirus 2C mutant has an uncoating defect.PMID 2154595Read ↗

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