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Article

An intragenic revertant of a poliovirus 2C mutant has an uncoating defect.

Journal of virology - 1 Mar 1990

Li J P, Baltimore D

Abstract excerpt

A revertant was isolated from a temperature-sensitive poliovirus 2C mutant, 2C-31, which is defective in viral RNA synthesis. This revertant, called 2C-31R1, grew well at 39 degrees C and was not defective in RNA synthesis. However, in contrast to its parental mutant, 2C-31R1 was cold sensitive and could hardly grow at all at 32 degrees C. Analysis of a single-cycle growth revealed that 2C-31R1 was defective in...

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Identifiers

PMID: 2154595
DOI: 10.1128/JVI.64.3.1102-1107.1990
PMCID: PMC249223

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