Article
An authentic 3' noncoding region is necessary for efficient poliovirus replication.
Journal of virology - 1 Sept 2005
Brown David M, Cornell Christopher T, Tran Genevieve P, Nguyen Joseph H C, Semler Bert L
Abstract excerpt
Picornavirus RNA replication involves the specific synthesis of negative-strand intermediates followed by an accumulation of positive-strand viral RNA in the presence of a multitude of cellular mRNAs. Previously, in an effort to identify cis-acting elements required for initiation of negative-str...
Topics
- 3' Untranslated Regions
- Base Sequence
- Computer Simulation
- DNA, Complementary
- DNA, Viral
- Genome, Viral
- HeLa Cells
- Humans
- Kinetics
- Models, Molecular
- Molecular Sequence Data
- Mutation
- Nucleic Acid Conformation
- Phenotype
- Poliovirus
- Protein Biosynthesis
- RNA Stability
- RNA, Viral