Mutation of the transforming growth factor-beta type II receptor gene in right-sided colorectal cancer: relationship to clinicopathological features and genetic alterations.

doi:10.1002/(SICI)1096-9896(199804)184:4<390::AID-PATH1230>3.0.CO;2-Q

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Article

Mutation of the transforming growth factor-beta type II receptor gene in right-sided colorectal cancer: relationship to clinicopathological features and genetic alterations.

The Journal of pathology - 1 Apr 1998

Iacopetta B J, Welch J, Soong R, House A K, Zhou X P, Hamelin R

Abstract excerpt

The presence of inactivating mutations in the transforming growth factor-beta (TGF-beta) type II receptor (RII) gene in the colon cancer suggests that it may behave like a tumour suppressor gene. RII is mutated in the majority of colon tumours exhibiting widespread microsatellite instability, a c...

Topics

Adenocarcinoma
Aged
Colorectal Neoplasms
Female
Follow-Up Studies
Humans
Male
Microsatellite Repeats
Middle Aged
Mutation
Neoplasm Proteins
Polymerase Chain Reaction
Polymorphism, Single-Stranded Conformational
Receptors, Transforming Growth Factor beta

Source

Open in PubMed

Identifiers

PMID: 9664904
DOI: 10.1002/(SICI)1096-9896(199804)184:4<390::AID-PATH1230>3.0.CO;2-Q

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 30 Aug 2026. Prepared record publication-9664904-2026-08-30.1. Manifest publication-graph-cohort-2026-08-30.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 30 Aug 2026.

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Survival Rate

Tumor Suppressor Protein p53