Article
A transforming growth factor beta type II receptor gene mutation common in sporadic cecum cancer with microsatellite instability.
Cancer research - 15 Dec 1996
Togo G, Toda N, Kanai F, Kato N, Shiratori Y, Kishi K, Imazeki F, Makuuchi M, Omata M
Abstract excerpt
Mismatch repair genes are the responsible genes for hereditary non-polyposis colon cancer, and mutation of these genes causes replication error (RER). In several RER-positive colon cancer cell lines, mutations of repetitive sequences of transforming growth factor beta (TGF-beta) type II receptor...
Topics
- Aged
- Cecal Neoplasms
- Colorectal Neoplasms
- DNA Replication
- Female
- Humans
- Male
- Middle Aged
- Mutation
- Protein Serine-Threonine Kinases
- Receptor, Transforming Growth Factor-beta Type II
- Receptors, Transforming Growth Factor beta
- Stomach Neoplasms