Article
G protein abnormalities in pituitary adenomas.
Molecular and cellular endocrinology - 25 Jul 1998
Spada A, Lania A, Ballarè E
Abstract excerpt
It has been demonstrated that the majority of secreting and nonsecreting adenomas is monoclonal in origin suggesting that these neoplasia arise from the replication of a single mutated cell, in which growth advantage results from either activation of protooncogenes or inactivation of antioncogenes. Although a large number of genes has been screened for mutations, only few genetic abnormalities have been found in...
Topics
- Adenoma
- Cyclic AMP
- GTP-Binding Protein alpha Subunits, Gi-Go
- GTP-Binding Protein alpha Subunits, Gs
- GTP-Binding Proteins
- Humans
- Mutation
- Pituitary Neoplasms
- Signal Transduction