Article
G protein abnormalities in pituitary adenomas.
Molecular and cellular endocrinology - 25 Jul 1998
Spada A, Lania A, Ballarè E
Abstract excerpt
It has been demonstrated that the majority of secreting and nonsecreting adenomas is monoclonal in origin suggesting that these neoplasia arise from the replication of a single mutated cell, in which growth advantage results from either activation of protooncogenes or inactivation of antioncogenes. Although a large number of genes has been screened for mutations, only few genetic abnormalities have been found in...
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