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Article

Mutant alpha subunits of G12 and G13 proteins induce neoplastic transformation of Rat-1 fibroblasts.

Oncogene - 1 Sept 1994

Voyno-Yasenetskaya T A, Pace A M, Bourne H R

Abstract excerpt

Mutationally activated alpha subunits of two G proteins, Gs and Gi2, induce neoplastic transformation of fibroblasts and are found in human tumors. Here we report that mutationally activated alpha subunits of two other G proteins, G12 and G13, induce neoplastic transformation of Rat-1 fibroblasts and NIH3T3 fibroblasts. Constitute activation of these alpha subunits resulted from replacement by leucine of...

Topics

3T3 Cells
Animals
Calcium-Calmodulin-Dependent Protein Kinases
Cell Transformation, Neoplastic
Cyclic AMP
Fibroblasts
GTP-Binding Proteins
Mice
Mutation
Rats
Type C Phospholipases

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Source

Identifiers

PMID: 8058319

Genes

EGF

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 29 Aug 2026. Prepared record publication-8058319-2026-08-29.1. Manifest publication-graph-cohort-2026-08-29.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 29 Aug 2026.

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