Article
A proliferative p53-responsive element mediates tumor necrosis factor alpha induction of the human immunodeficiency virus type 1 long terminal repeat.
Molecular and cellular biology - 1 Jun 1995
Gualberto A, Hixon M L, Finco T S, Perkins N D, Nabel G J, Baldwin A S
Abstract excerpt
Transforming mutants of the p53 tumor suppressor gene can positively regulate transcription from several promoters that do not contain known p53 binding sites. Here, we report the identification of a novel p53 binding site in the human immunodeficiency virus long terminal repeat that specifically...
Topics
- Base Sequence
- Binding Sites
- HIV-1
- Humans
- Molecular Sequence Data
- Mutation
- Repetitive Sequences, Nucleic Acid
- T-Lymphocytes
- Transcriptional Activation
- Tumor Cells, Cultured
- Tumor Necrosis Factor-alpha
- Tumor Suppressor Protein p53