Article
A supercoil-dependent structural alteration within the regulatory region of the human transferrin receptor gene.
Biochemical and biophysical research communications - 28 Feb 1992
Ouyang Q, Miskimins W K
Abstract excerpt
The transferrin receptor gene is transcribed at low levels in quiescent cells and at much higher levels in growing or transformed cells. This regulation involves elements located within the first 114 base pairs upstream of the major transcriptional start site. This region is specifically recognized by several transacting factors and contains an element that is composed of alternating purines and pyrimidines. In...
Topics
- Base Sequence
- DNA, Superhelical
- Diethyl Pyrocarbonate
- Humans
- Molecular Sequence Data
- Mutation
- Nucleic Acid Conformation
- Plasmids
- Promoter Regions, Genetic
- Receptors, Transferrin
- Regulatory Sequences, Nucleic Acid