Article
Repression of the human immunodeficiency virus type-1 long terminal repeat by the c-Myc oncoprotein.
Journal of cellular biochemistry - 15 May 2004
Stojanova A, Caro C, Jarjour R J V, Oster S K, Penn L Z, Germinario R J
Abstract excerpt
The effect of trans-acting factors on cis-acting DNA elements on the HIV-1 promoter are the principal determinant regulating transcriptional activation and repression. Host factors that limit viral replication can contribute to the emergence and maintenance of proviral reservoirs. The current paradigm is that this sub-population of latently infected cells confers a biological advantage to the virus by...
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