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Article

Structural and functional analysis of p53: the acidic activation domain has transforming capability.

Cell growth & differentiation : the molecular biology journal of the American Association for Cancer Research - 1 Oct 1994

Hulboy D L, Lozano G

Abstract excerpt

The p53 gene encodes a transcriptional activator that is able to suppress transformation. The protein can be divided into three functional domains: the acidic activation domain at the amino terminus; the oligomerization and nonspecific DNA binding regions in the carboxyl terminus; and the conformation domain, responsible for specific DNA binding, in the middle. To further examine the structural/functional...

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PMID: 7848903

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

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Structural and functional analysis of p53: the acidic activation domain has transforming capability.PMID 7848903Read ↗

The requirement of the carboxyl terminus of p53 for DNA binding and transcriptional activation depends on the specific p53 binding DNA element.Semantic proximity Read ↗

Functional domains of wild-type and mutant p53 proteins involved in transcriptional regulation, transdominant inhibition, and transformation suppression.Semantic proximity Read ↗

The basic carboxy-terminal domain of human p53 is dispensable for both transcriptional regulation and inhibition of tumor cell growth.Semantic proximity Read ↗

p53 linear diffusion along DNA requires its C terminus.Semantic proximity Read ↗

p53: a transdominant regulator of transcription whose function is ablated by mutations occurring in human cancer.Semantic proximity Read ↗

Mutational analysis of the carboxy-terminal portion of p53 using both yeast and mammalian cell assays in vivo.Semantic proximity Read ↗

Presence of a Potent Transcription Activating Sequence in the p53 ProteinSemantic proximity Read ↗

Mutant p53 proteins have diverse intracellular abilities to oligomerize and activate transcription.Semantic proximity Read ↗

Analysis of p53 mutants for transcriptional activity.Semantic proximity Read ↗

Function, oligomerization, and conformation of tumor-associated p53 proteins with mutated C-terminus.Semantic proximity Read ↗

A proteolytic fragment from the central region of p53 has marked sequence-specific DNA-binding activity when generated from wild-type but not from oncogenic mutant p53 protein.Semantic proximity Read ↗

p53 Oligomerization is essential for its C-terminal lysine acetylation.Semantic proximity Read ↗

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