Structural and functional analysis of p53: the acidic activation domain has transforming capability.

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Article

Structural and functional analysis of p53: the acidic activation domain has transforming capability.

Cell growth & differentiation : the molecular biology journal of the American Association for Cancer Research - 1 Oct 1994

Hulboy D L, Lozano G

Abstract excerpt

The p53 gene encodes a transcriptional activator that is able to suppress transformation. The protein can be divided into three functional domains: the acidic activation domain at the amino terminus; the oligomerization and nonspecific DNA binding regions in the carboxyl terminus; and the conform...

Topics

Acids
Amino Acid Sequence
Base Sequence
Gene Deletion
Genes, p53
Humans
Molecular Sequence Data
Mutation
Protein Structure, Tertiary
Proto-Oncogene Proteins
Structure-Activity Relationship
Transcriptional Activation
Transformation, Genetic

Source

Open in PubMed

Identifiers

PMID: 7848903

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 30 Aug 2026. Prepared record publication-7848903-2026-08-30.1. Manifest publication-graph-cohort-2026-08-30.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 30 Aug 2026.

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