Article
Differentiation of CD4(high)CD8(low) coreceptor-skewed thymocytes into mature CD8 single-positive cells independent of MHC class I recognition.
European journal of immunology - 1 Aug 1997
Barthlott T, Kohler H, Pircher H, Eichmann K
Abstract excerpt
Thymocytes with a CD4(hi)CD8(lo) coreceptor-skewed (CRS) phenotype have been shown to contain precursors for CD8 single-positive (SP) thymocytes, in addition to precursors for CD4 SP cells. The selection mechanisms that stimulate CD4(hi)CD8(lo) cells to revert to the CD8 lineage are not known. Mi...
Topics
- Animals
- CD4 Antigens
- CD8 Antigens
- Calcium
- Cell Differentiation
- Down-Regulation
- Female
- H-2 Antigens
- In Vitro Techniques
- Ion Transport
- Lymphocyte Activation
- Mice
- Mice, Inbred BALB C
- Mice, Inbred C57BL
- Mice, Transgenic
- Phenotype
- Pregnancy
- Receptors, Antigen, T-Cell