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Article

Empty MHC class I molecules come out in the cold.

Nature - 2 Aug 1990

Ljunggren H G, Stam N J, Ohlén C, Neefjes J J, Höglund P, Heemels M T, Bastin J, Schumacher T N, Townsend A, Kärre K

Abstract excerpt

Major histocompatibility complex (MHC) class I molecules present antigen by transporting peptides from intracellularly degraded proteins to the cell surface for scrutiny by cytotoxic T cells. Recent work suggests that peptide binding may be required for efficient assembly and intracellular transport of MHC class I molecules, but it is not clear whether class I molecules can ever assemble in the absence of...

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PMID: 2198471
DOI: 10.1038/346476a0

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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