Article
Empty MHC class I molecules come out in the cold.
Nature - 2 Aug 1990
Ljunggren H G, Stam N J, Ohlén C, Neefjes J J, Höglund P, Heemels M T, Bastin J, Schumacher T N, Townsend A, Kärre K
Abstract excerpt
Major histocompatibility complex (MHC) class I molecules present antigen by transporting peptides from intracellularly degraded proteins to the cell surface for scrutiny by cytotoxic T cells. Recent work suggests that peptide binding may be required for efficient assembly and intracellular transp...
Topics
- Animals
- Antigen-Presenting Cells
- Biological Transport
- Cell Membrane
- Cold Temperature
- H-2 Antigens
- Lymphoma
- Macromolecular Substances
- Mice
- Mutation
- Protein Binding
- Protein Conformation
- Protein Processing, Post-Translational
- T-Lymphocytes, Cytotoxic
- Tumor Cells, Cultured
- beta 2-Microglobulin