Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

The ataxia telangiectasia-mutated target site Ser18 is required for p53-mediated tumor suppression.

Cancer research - 15 Dec 2007

Armata Heather L, Garlick David S, Sluss Hayla K

Abstract excerpt

The p53 tumor suppressor is phosphorylated at multiple sites within its NH(2)-terminal region. One of these phosphorylation sites (mouse Ser(18) and human Ser(15)) is a substrate for the ataxia telangiectasia-mutated (ATM) and ATM-related (ATR) protein kinases. Studies of p53(S18A) mice (with a g...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Cell Cycle Proteins
Share to Ataxia Telangiectasia Mutated Proteins
Share to Cell Division

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Cellular Senescence

Share to Embryo, Mammalian

Share to Fibroblasts

Share to Germ-Line Mutation

Share to Serine

Source

Identifiers

PMID: 18089799
DOI: 10.1158/0008-5472.CAN-07-1610

Genes

ATM
ATR

Variants

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 2 Sept 2026. Prepared record publication-18089799-2026-09-02.2. Manifest publication-graph-cohort-2026-09-02.2.

Source receipt: PubMed via Helena Literature Corpus, retrieved 2 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

The ataxia telangiectasia-mutated target site Ser18 is required for p53-mediated tumor suppression.PMID 18089799Read ↗

Loss of p53 Ser18 and Atm results in embryonic lethality without cooperation in tumorigenesis.Semantic proximity Read ↗

Cell Type- and Promoter-specific Roles of Ser18 Phosphorylation in Regulating p53 ResponsesSemantic proximity Read ↗

Ser18 and 23 phosphorylation is required for p53-dependent apoptosis and tumor suppression.Semantic proximity Read ↗

The haploinsufficient tumor suppressor p18 upregulates p53 via interactions with ATM/ATR.Semantic proximity Read ↗

Phosphorylation Control of p53 DNA-Binding Cooperativity Balances Tumorigenesis and AgingSemantic proximity Read ↗

The p53 R181C mutation accumulates through impaired deacetylation by Sirt1 and facilitates tumor development.Semantic proximity Read ↗

Tumor suppression in the absence of p53-mediated cell-cycle arrest, apoptosis, and senescence.Semantic proximity Read ↗

Double-stranded-RNA-activated protein kinase PKR enhances transcriptional activation by tumor suppressor p53.Semantic proximity Read ↗

mTOR inhibition acts as an unexpected checkpoint in p53-mediated tumor suppression.Semantic proximity Read ↗

Requirement of the ATM/p53 tumor suppressor pathway for glucose homeostasis.Semantic proximity Read ↗

RB18A enhances expression of mutant p53 protein in human cells.Semantic proximity Read ↗

G2/M transition requires multisite phosphorylation of oncoprotein 18 by two distinct protein kinase systems.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.