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Article

A p53 amino-terminal nuclear export signal inhibited by DNA damage-induced phosphorylation.

Science (New York, N.Y.) - 8 Jun 2001

Zhang Y, Xiong Y

Abstract excerpt

The p53 protein is present in low amounts in normally growing cells and is activated in response to physiological insults. MDM2 regulates p53 either through inhibiting p53's transactivating function in the nucleus or by targeting p53 degradation in the cytoplasm. We identified a previously unknown nuclear export signal (NES) in the amino terminus of p53, spanning residues 11 to 27 and containing two serine...

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Source

Identifiers

PMID: 11397945
DOI: 10.1126/science.1058637

Genes

MDM2
NES

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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