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Article

Phosphorylation of specific serine residues in the PKR activation domain of PACT is essential for its ability to mediate apoptosis.

The Journal of biological chemistry - 17 Nov 2006

Peters Gregory A, Li Shoudong, Sen Ganes C

Abstract excerpt

Activation of the latent protein kinase, PKR, by extracellular stresses and triggering of resultant cellular apoptosis are mediated by the protein, PACT, which itself gets phosphorylated in stressed cells. We have analyzed the underlying biochemical mechanism by carrying out alanine-scanning mutagenesis of the PKR activation domain of PACT. Among the indispensable residues identified were two serine residues,...

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Identifiers

PMID: 16982605
DOI: 10.1074/jbc.M607714200

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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