Article
Several hydrophobic amino acids in the p53 amino-terminal domain are required for transcriptional activation, binding to mdm-2 and the adenovirus 5 E1B 55-kD protein.
Genes & development - 15 May 1994
Lin J, Chen J, Elenbaas B, Levine A J
Abstract excerpt
The p53 tumor suppressor gene product is a transcriptional activator that may be associated with its ability to suppress tumor cell growth. The acidic amino terminus of the p53 protein has been shown to contain this trans-activation activity as well as the domains for mdm-2 and adenovirus 5 E1B 5...
Topics
- Adenovirus E1B Proteins
- Amino Acid Sequence
- Amino Acids
- Consensus Sequence
- DNA-Binding Proteins
- Humans
- Molecular Sequence Data
- Mutation
- Neoplasm Proteins
- Nuclear Proteins
- Polydeoxyribonucleotides
- Protein Binding
- Proto-Oncogene Proteins
- Proto-Oncogene Proteins c-mdm2
- TATA Box
- TATA-Box Binding Protein
- Transcription Factors
- Transcriptional Activation