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Article

Insights into the limitations of transient expression systems for the functional study of p53 acetylation site and oncogenic mutants.

Biochemical and biophysical research communications - 16 Apr 2020

Bruer Marius, Reinhardt Dirk, Welte Karl, Thakur Basant Kumar

Abstract excerpt

Tumor suppressor protein p53 protects cells against malignant transformation mostly through transcriptional activation. Lysine acetylation is required to mediate activation of p53. The protein displays eight lysine residues and their evolutionary conservation argues for an essential role. The aim of this study was to investigate the significance of individual acetylation sites in mediating p53 functions....

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Source

Identifiers

PMID: 32061389
DOI: 10.1016/j.bbrc.2020.02.002

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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