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Article

Correlations between apolipoprotein E epsilon4 gene dose and whole brain atrophy rates.

The American journal of psychiatry - 1 Jun 2007

Chen Kewei, Reiman Eric M, Alexander Gene E, Caselli Richard J, Gerkin Richard, Bandy Daniel, Domb Alisa, Osborne David, Fox Nick, Crum William R, Saunders Ann M, Hardy John

Abstract excerpt

OBJECTIVE: The purpose of this study was to characterize the relationship between whole brain atrophy rates and three levels of genetic risk for Alzheimer's disease in cognitively normal persons. The authors previously found accelerated whole brain atrophy rates in patients with probable Alzheimer's disease by computing changes in brain volume from sequential magnetic resonance images (MRIs). METHODS: The authors...

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Source

Identifiers

PMID: 17541051
DOI: 10.1176/ajp.2007.164.6.916

Genes

APOE

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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