Article
HLA and ethnic associations among systemic sclerosis patients with anticentromere antibodies.
Human immunology - 1 Jan 1995
Morel P A, Chang H J, Wilson J W, Conte C, Falkner D, Tweardy D J, Medsger T A
Abstract excerpt
SSc with ACAs is characterized by limited cutaneous involvement and, in most patients, a mild protracted course. We have studied 104 SSc patients, 47 with ACAs and 57 who were negative for both ACAs and anti-topo I antibodies, for HLA-DR and -DQ associations using DNA typing techniques. Normal controls consisted of 181 healthy individuals. A significant association was observed in the ACA-positive patients with...
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