Article
Association of HLA class II genes with systemic sclerosis in Spanish patients.
The Journal of rheumatology - 1 Dec 2009
Simeón Carmen P, Fonollosa Vicent, Tolosa Carles, Palou Eduard, Selva Albert, Solans Roser, Armadans Lluis, Moreno Estefania, Marsal Sara, Vilardell Miquel
Abstract excerpt
OBJECTIVE: To examine the role of HLA-DRB1 and HLA-DQB1 alleles in the susceptibility to systemic sclerosis (SSc) and its clinical expression in a Spanish population. METHODS: One hundred Spanish Caucasian patients with SSc and 130 controls were studied. Molecular HLA-DRB1 and HLA-DQB1 typing was performed by polymerase chain reaction (PCR) sequence-based typing and PCR sequence-specific oligonucleotide. RESULTS:...
Topics
- Adolescent
- Adult
- Aged
- Alleles
- Autoantibodies
- Female
- Genes, MHC Class II
- Genetic Predisposition to Disease
- HLA-DQ Antigens
- HLA-DQ beta-Chains
- HLA-DR Antigens
- HLA-DRB1 Chains
- Humans
- Male