An allograft inflammatory factor 1 (AIF1) single nucleotide polymorphism (SNP) is associated with anticentromere antibody positive systemic sclerosis.

doi:10.1093/rheumatology/kem057

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Article

An allograft inflammatory factor 1 (AIF1) single nucleotide polymorphism (SNP) is associated with anticentromere antibody positive systemic sclerosis.

Rheumatology (Oxford, England) - 1 Aug 2007

Alkassab F, Gourh P, Tan F K, McNearney T, Fischbach M, Ahn C, Arnett F C, Mayes M D

Abstract excerpt

OBJECTIVE: To identify genetic associations between allograft inflammatory factor 1 (AIF1) and systemic sclerosis (SSc), or its subsets, using a single nucleotide polymorphism (SNP) in a replicate case-control study. METHODS: The frequencies of alleles and genotypes of an SNP, rs2269475, for the AIF1 gene were examined in two large independent cohorts of SSc patients (n = 1015 total), and compared with two groups...

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PMID: 17522098
DOI: 10.1093/rheumatology/kem057

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AIF1

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