Article
HLA-DQB1 associations with anti-topoisomerase-1 antibodies in patients with systemic sclerosis and their first degree relatives. United Kingdom Systemic Sclerosis Study Group.
Journal of autoimmunity - 1 Aug 1994
Whyte J, Artlett C, Harvey G, Stephens C O, Welsh K, Black C, Maddison P J, McHugh N J
Abstract excerpt
The frequency and functional properties of anti-topoisomerase-1 antibodies (ATA) have been studied in 58 systemic sclerosis (SSc) probands, 218 first degree relatives and 22 spouses. The dependence of ATA on the presence of certain HLA-DRB1 and HLA-DQB1 alleles was examined. ATA were detected by...
Topics
- Alleles
- Autoimmune Diseases
- DNA Topoisomerases, Type I
- Disease Susceptibility
- Genes, MHC Class II
- Genetic Predisposition to Disease
- HLA-DQ Antigens
- HLA-DQ beta-Chains
- Haplotypes
- Humans
- Nuclear Family
- Parents
- Pedigree
- Russia
- Scleroderma, Systemic