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Article

Severe systemic sclerosis with anti-topoisomerase I antibodies is associated with an HLA-DRw11 allele.

Human immunology - 1 Jun 1994

Morel P A, Chang H J, Wilson J W, Conte C, Saidman S L, Bray J D, Tweardy D J, Medsger T A

Abstract excerpt

SSc is an autoimmune connective tissue disease in which strong HLA associations have not been described. Anti-topo I antibodies are recognized, in general, in SSc patients with diffuse cutaneous involvement, whereas anti-ACAs are found in individuals with limited cutaneous involvement. We studied...

Topics

Adult
Alleles
Autoantibodies
DNA Topoisomerases, Type I
Female
Gene Frequency
HLA-DQ Antigens
HLA-DR Antigens
Humans
Male
Middle Aged
Scleroderma, Systemic

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Source

Identifiers

PMID: 7928439
DOI: 10.1016/0198-8859(94)90054-x

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 30 Aug 2026. Prepared record publication-7928439-2026-08-30.1. Manifest publication-graph-cohort-2026-08-30.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 30 Aug 2026.

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