Anti-centromere antibodies (ACA) in systemic sclerosis patients and their relatives: a serological and HLA study.

doi:10.1111/j.1365-2249.1994.tb06552.x

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Article

Anti-centromere antibodies (ACA) in systemic sclerosis patients and their relatives: a serological and HLA study.

Clinical and experimental immunology - 1 May 1994

McHugh N J, Whyte J, Artlett C, Briggs D C, Stephens C O, Olsen N J, Gusseva N G, Maddison P J, Black C M, Welsh K

Abstract excerpt

Autoantibody reactivity to centromere proteins CENP-A, CENP-B and CENP-C was examined in 58 patients with systemic sclerosis (SSc), 218 first degree relatives and 22 spouses. HLA class II typing for HLA-DRB1 and HLA-DQA1 was performed by restriction fragment length polymorphism (RFLP) analysis in...

Topics

Alleles
Autoantibodies
Autoantigens
Centromere
Centromere Protein A
Centromere Protein B
Chromosomal Proteins, Non-Histone
DNA-Binding Proteins
Diseases in Twins
Female
Genes, MHC Class II
HLA-DQ Antigens
HLA-DQ alpha-Chains
HLA-DQ beta-Chains

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

HLA-DR Antigens

HLA-DRB1 Chains

Histocompatibility Antigens Class II

Humans

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Identifiers

PMID: 8187334
DOI: 10.1111/j.1365-2249.1994.tb06552.x
PMCID: PMC1534886

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 30 Aug 2026. Prepared record publication-8187334-2026-08-30.1. Manifest publication-graph-cohort-2026-08-30.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 30 Aug 2026.