Article
Association of polar amino acids at position 26 of the HLA-DQB1 first domain with the anticentromere autoantibody response in systemic sclerosis (scleroderma).
The Journal of clinical investigation - 1 Apr 1992
Reveille J D, Owerbach D, Goldstein R, Moreda R, Isern R A, Arnett F C
Abstract excerpt
HLA class II alleles (detected by DNA typing) were determined in 116 Caucasians with systemic sclerosis positive and negative for anticentromere autoantibodies (ACA). Significantly increased frequencies of HLA-DR5(DRw11) (P = 0.009) and the Dw13(DRB1*0403, *0407) subtypes of DR4 (probability corrected, Pc = 0.005) were seen in ACA positive patients, and HLA-DR1 and DRw8 were also increased. These findings...
Topics
- Alleles
- Autoantibodies
- Base Sequence
- Centromere
- Gene Frequency
- HLA-DQ Antigens
- HLA-DQ beta-Chains
- HLA-DR Antigens
- Haplotypes
- Humans
- Molecular Sequence Data