Mechanisms of glucose-induced secretion of pancreatic-derived factor (PANDER or FAM3B) in pancreatic beta-cells.

doi:10.2337/diabetes.54.11.3217

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Back to search

Article

Mechanisms of glucose-induced secretion of pancreatic-derived factor (PANDER or FAM3B) in pancreatic beta-cells.

Diabetes - 1 Nov 2005

Yang Jichun, Robert Claudia E, Burkhardt Brant R, Young Robert A, Wu Jianmei, Gao Zhiyong, Wolf Bryan A

Abstract excerpt

Pancreatic-derived factor (PANDER) is an islet-specific cytokine present in both pancreatic alpha- and beta-cells, which, in vitro, induces beta-cell apoptosis of primary islet and cell lines. In this study, we investigated whether PANDER is secreted by pancreatic alpha- and beta-cells and whether PANDER secretion is regulated by glucose and other insulin secretagogues. In mouse-derived insulin-secreting beta-TC3...

Topics

Amino Acid Sequence
Animals
Cell Line
Cytokines
Dose-Response Relationship, Drug
Glucose
Glutamine
Insulin-Secreting Cells
Leucine
Mice
Mutation
Nifedipine
Potassium Chloride
Time Factors

Source

Open in PubMed

Identifiers

PMID: 16249448
DOI: 10.2337/diabetes.54.11.3217

Genes

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 30 Aug 2026.

Community interpretation

Discuss the evidence

Ask a question, add context or challenge an interpretation. Community activity is separate from scientific evidence strength.

discussions

replies

Citations encouraged

Claims remain attributable.

No discussion yet

Be the first to add a careful, cited interpretation.

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics