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Mechanisms of glucose-induced secretion of pancreatic-derived factor (PANDER or FAM3B) in pancreatic beta-cells.

Diabetes - 1 Nov 2005

Yang Jichun, Robert Claudia E, Burkhardt Brant R, Young Robert A, Wu Jianmei, Gao Zhiyong, Wolf Bryan A

Abstract excerpt

Pancreatic-derived factor (PANDER) is an islet-specific cytokine present in both pancreatic alpha- and beta-cells, which, in vitro, induces beta-cell apoptosis of primary islet and cell lines. In this study, we investigated whether PANDER is secreted by pancreatic alpha- and beta-cells and whether PANDER secretion is regulated by glucose and other insulin secretagogues. In mouse-derived insulin-secreting beta-TC3...

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PMID: 16249448
DOI: 10.2337/diabetes.54.11.3217

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

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