Functional effects of transgenic expression of cholera toxin in pancreatic beta-cells.

doi:10.1016/0303-7207(93)90233-a

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Article

Functional effects of transgenic expression of cholera toxin in pancreatic beta-cells.

Molecular and cellular endocrinology - 1 Dec 1993

Wogensen L, Ma Y H, Grodsky G M, Robertson R P, Burton F, Sutcliffe J G, Sarvetnick N

Abstract excerpt

Investigation of intracellular pathways of stimulus-secretion signaling in vivo is possible by transgenic expression of agents known to influence specific biochemical interactions in the cells. The objective of the present study was to establish an experimental model for analyzing signal transduc...

Topics

1-Methyl-3-isobutylxanthine
Animals
Base Sequence
Cholera Toxin
Colforsin
Cyclic AMP
Female
GTP-Binding Proteins
Glucose
Humans
Hyperglycemia
Insulin
Insulin Secretion
Islets of Langerhans
Male
Mice
Mice, Inbred BALB C
Mice, Transgenic

Source

Open in PubMed

Identifiers

PMID: 7511546
DOI: 10.1016/0303-7207(93)90233-a

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 30 Aug 2026. Prepared record publication-7511546-2026-08-30.1. Manifest publication-graph-cohort-2026-08-30.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 30 Aug 2026.

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