Article
Defective glycolysis and calcium signaling underlie impaired insulin secretion in a transgenic mouse.
The Journal of biological chemistry - 1 Dec 1995
Ribar T J, Jan C R, Augustine G J, Means A R
Abstract excerpt
Pancreatic beta cells from mice that overexpress the Ca(2+)-binding protein calmodulin have a unique secretory defect that leads to chronic hyperglycemia. To further understand the molecular basis underlying this defect, we have studied signaling pathways in these beta cells. Measurements of cyto...
Topics
- Adenosine Triphosphate
- Animals
- Calcium
- Calcium Channels
- Calmodulin
- Glucose
- Glycolysis
- Insulin
- Insulin Secretion
- Islets of Langerhans
- Membrane Potentials
- Mice
- Mice, Transgenic
- Mutation
- Potassium Channel Blockers
- Potassium Channels
- Signal Transduction
- Tolbutamide