Adaptation to hyperglycemia enhances insulin secretion in glucokinase mutant mice.

doi:10.2337/diabetes.47.12.1881

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Article

Adaptation to hyperglycemia enhances insulin secretion in glucokinase mutant mice.

Diabetes - 1 Dec 1998

Sreenan S K, Cockburn B N, Baldwin A C, Ostrega D M, Levisetti M, Grupe A, Bell G I, Stewart T A, Roe M W, Polonsky K S

Abstract excerpt

The present study was undertaken to test the hypothesis that exposure to high glucose concentrations enhances insulin secretion in pancreatic islets from glucokinase-deficient mice. Insulin secretion and intracellular calcium ([Ca2+]i) were measured as the glucose concentration was increased from...

Topics

Animals
Blood Glucose
Body Weight
Calcium
Dose-Response Relationship, Drug
Glucokinase
Glucose
Glucose Tolerance Test
Hyperglycemia
Insulin
Insulin Secretion
Islets of Langerhans
Mice
Mutation

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