Article
Adaptation to hyperglycemia enhances insulin secretion in glucokinase mutant mice.
Diabetes - 1 Dec 1998
Sreenan S K, Cockburn B N, Baldwin A C, Ostrega D M, Levisetti M, Grupe A, Bell G I, Stewart T A, Roe M W, Polonsky K S
Abstract excerpt
The present study was undertaken to test the hypothesis that exposure to high glucose concentrations enhances insulin secretion in pancreatic islets from glucokinase-deficient mice. Insulin secretion and intracellular calcium ([Ca2+]i) were measured as the glucose concentration was increased from 2 to 26 mmol/l in islets from heterozygous glucokinase (GK)-deficient mice (GK+/-) and their wild-type littermates...
Read the complete abstract on PubMedTopics
Share this publication in a Topic to start or enrich a Post.