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Article

Mismatch repair, genetic stability and tumour avoidance.

Philosophical transactions of the Royal Society of London. Series B, Biological sciences - 30 Jan 1995

Modrich P

Abstract excerpt

Escherichia coli methyl-directed mismatch repair eliminates premutagenic lesions that arise via DNA biosynthetic errors; components of the repair system also block ectopic recombination between diverged DNA sequences. A mismatch-dependent, methyl-directed excision reaction that accounts for function of the system in replication fidelity has been reconstituted in a purified system dependent on ten activities. The...

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Identifiers

PMID: 7746860
DOI: 10.1098/rstb.1995.0014

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