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Article

DNA damage tolerance, mismatch repair and genome instability

1 Nov 1994

Abstract excerpt

DNA mismatch repair is an important pathway of mutation avoidance. It also contributes to the cytotoxic effects of some kinds of DNA damage, and cells defective in mismatch repair are resistant, or tolerant, to the presence of some normally cytotoxic base analogues in their DNA. The absence of a particular mismatch binding function from some mammalian cells confers resistance to the base analogues...

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PMID: 7840761
DOI: 10.1002/bies.950161110

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