Genetic instability and methylation tolerance in colon cancer.

Abstract excerpt

Microsatellite instability was first identified in colon cancer and later shown to be due to mutations in genes responsible for correction of DNA mismatches. Several human mismatch correction genes that are homologous to those of yeast and bacteria have been identified and are mutated in families affected by the hereditary non-polyposis colorectal carcinoma (HNPCC) syndrome. Similar alterations have been also...

Topics

Share this publication in a Topic to start or enrich a Post.

• Share to Cell Transformation, Neoplastic
• Share to Colorectal Neoplasms
• Share to DNA Damage