Article
Transcription-coupled repair deficiency and mutations in human mismatch repair genes.
Science (New York, N.Y.) - 26 Apr 1996
Mellon I, Rajpal D K, Koi M, Boland C R, Champe G N
Abstract excerpt
Deficiencies in mismatch repair have been linked to a common cancer predisposition syndrome in humans, hereditary nonpolyposis colorectal cancer (HNPCC), and a subset of sporadic cancers. Here, several mismatch repair-deficient tumor cell lines and HNPCC-derived lymphoblastoid cell lines were found to be deficient in an additional DNA repair process termed transcription-coupled repair (TCR). The TCR defect was...
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