Article
DNA-replication fidelity, mismatch repair and genome instability in cancer cells.
European journal of biochemistry - 1 Jun 1996
Umar A, Kunkel T A
Abstract excerpt
It has been suggested that an early event in the multistep progression of a normal cell to a tumor cell could be a defect that leads to an elevated mutation rate, thus providing a pool of mutants upon which selection could act to yield a tumor. Such a mutator phenotype could result from a defect in any of several DNA transactions, including those that determine the DNA replication error rate or the ability to...
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