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Article

Ligand-independent activation of the platelet-derived growth factor beta receptor: requirements for bovine papillomavirus E5-induced mitogenic signaling.

Molecular and cellular biology - 1 May 1995

Drummond-Barbosa D, Vaillancourt R R, Kazlauskas A, DiMaio D

Abstract excerpt

The E5 protein of bovine papillomavirus type 1 binds to and activates the endogenous platelet-derived growth factor (PDGF) beta receptor in fibroblasts, resulting in cell transformation. We have developed a functional assay to test the ability of PDGF beta receptor mutants to mediate a mitogenic signal initiated by the E5 protein. Lymphoid Ba/F3 cells are strictly dependent on interleukin-3 for growth, but...

Topics

Animals
Binding Sites
Bovine papillomavirus 1
Cell Division
Cell Line
Humans
Ligands
Mice
Mitogens
Mutation
Oncogene Proteins, Viral

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Phosphorylation

Protein-Tyrosine Kinases

Receptors, Platelet-Derived Growth Factor

Signal Transduction

Source

Open in PubMed Open full text

Identifiers

PMID: 7739538
DOI: 10.1128/MCB.15.5.2570
PMCID: PMC230487

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 29 Aug 2026. Prepared record publication-7739538-2026-08-29.1. Manifest publication-graph-cohort-2026-08-29.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 29 Aug 2026.

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