Article
Similar CD40 ligand expression on EL-4 thymoma cell lines with widely different helper activity for B lymphocytes.
Immunology - 1 Jan 1994
Werner-Favre C, Gauchat J F, Mazzei G, Aubry J P, Bonnefoy J Y, Zubler R H
Abstract excerpt
A mutagenized subclone of the murine EL-4 thymoma (clone B5) is approximately 30 times more potent than parental EL-4 cells in stimulating proliferation and Ig secretion of murine or human B cells by direct cell contact in the presence of appropriate cytokines. In this study we found that CD40 li...
Topics
- Animals
- Antigens, CD
- Antigens, Differentiation, B-Lymphocyte
- B-Lymphocytes
- Blotting, Northern
- CD40 Antigens
- Humans
- Ligands
- Lymphocyte Activation
- Lymphocyte Cooperation
- Mice
- Mutation
- T-Lymphocytes, Helper-Inducer
- Thymoma
- Thymus Neoplasms
- Tumor Cells, Cultured