Article
Similar CD40 ligand expression on EL-4 thymoma cell lines with widely different helper activity for B lymphocytes.
Immunology - 1 Jan 1994
Werner-Favre C, Gauchat J F, Mazzei G, Aubry J P, Bonnefoy J Y, Zubler R H
Abstract excerpt
A mutagenized subclone of the murine EL-4 thymoma (clone B5) is approximately 30 times more potent than parental EL-4 cells in stimulating proliferation and Ig secretion of murine or human B cells by direct cell contact in the presence of appropriate cytokines. In this study we found that CD40 ligand (CD40L) expression was constitutive and very similar on EL-4 B5 and parental EL-4 cells according to Northern blot...
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