E5 oncoprotein retained in the endoplasmic reticulum/cis Golgi still induces PDGF receptor autophosphorylation but does not transform cells.

doi:10.1002/j.1460-2075.1995.tb07308.x

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Back to search

Article

E5 oncoprotein retained in the endoplasmic reticulum/cis Golgi still induces PDGF receptor autophosphorylation but does not transform cells.

The EMBO journal - 3 Jul 1995

Sparkowski J, Anders J, Schlegel R

Abstract excerpt

The E5 oncoprotein encoded by bovine papillomavirus type 1 is a homodimeric, hydrophobic polypeptide which is localized predominantly in Golgi membranes and which transforms several cell types apparently by inducing tyrosine phosphorylation of the platelet-derived growth factor receptor (PDGF-R). While the precise mechanism of receptor activation is unknown, E5 associates with several cellular proteins, including...

Topics

3T3 Cells
Amino Acid Sequence
Animals
Base Sequence
Cell Line, Transformed
Cells, Cultured
Endoplasmic Reticulum
Gene Expression Regulation
Golgi Apparatus
Mice
Molecular Sequence Data

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Mutation

Oligopeptides

Oncogene Proteins, Viral

Phosphorylation

Protein Sorting Signals

Proton-Translocating ATPases

Receptors, Platelet-Derived Growth Factor

Source

Open in PubMed Open full text

Identifiers

PMID: 7621820
DOI: 10.1002/j.1460-2075.1995.tb07308.x
PMCID: PMC394366

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 29 Aug 2026. Prepared record publication-7621820-2026-08-29.1. Manifest publication-graph-cohort-2026-08-29.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 29 Aug 2026.

Community interpretation

Discuss the evidence

Ask a question, add context or challenge an interpretation. Community activity is separate from scientific evidence strength.

discussions

replies

Citations encouraged

Claims remain attributable.

No discussion yet

Be the first to add a careful, cited interpretation.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

E5 oncoprotein retained in the endoplasmic reticulum/cis Golgi still induces PDGF receptor autophosphorylation but does not transform cells.PMID 7621820Read ↗

The E5 oncoprotein of bovine papillomavirus binds to a 16 kd cellular protein.Semantic proximity Read ↗

The platelet-derived growth factor beta receptor as a target of the bovine papillomavirus E5 protein.Semantic proximity Read ↗

Golgi alkalinization by the papillomavirus E5 oncoprotein.Semantic proximity Read ↗

The E5 proteins.Semantic proximity Read ↗

Ligand-independent activation of the platelet-derived growth factor beta receptor: requirements for bovine papillomavirus E5-induced mitogenic signaling.Semantic proximity Read ↗

Role of glutamine 17 of the bovine papillomavirus E5 protein in platelet-derived growth factor beta receptor activation and cell transformation.Semantic proximity Read ↗

A papillomavirus E2 phosphorylation mutant exhibits normal transient replication and transcription but is defective in transformation and plasmid retention.Semantic proximity Read ↗

Human papillomavirus E5 oncoproteins bind the A4 endoplasmic reticulum protein to regulate proliferative ability upon differentiationSemantic proximity Read ↗

Specific locations of hydrophilic amino acids in constructed transmembrane ligands of the platelet-derived growth factor beta receptor.Semantic proximity Read ↗

Molecular examination of the transmembrane requirements of the platelet-derived growth factor beta receptor for a productive interaction with the bovine papillomavirus E5 oncoprotein.Semantic proximity Read ↗

The bovine papillomavirus E5 protein requires a juxtamembrane negative charge for activation of the platelet-derived growth factor beta receptor and transformation of C127 cells.Semantic proximity Read ↗

Down-regulation of MHC class I by bovine papillomavirus E5 oncoproteins.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.