Article
The role of exogenous p53 and E6 oncoproteins in in vitro transformation by bovine papillomavirus type 4 (BPV-4): significance of the absence of an E6 ORF in the BPV-4 genome.
The Journal of general virology - 1 Nov 1997
Scobie L, Jackson M E, Campo M S
Abstract excerpt
Bovine papillomavirus type 4 (BPV-4) does not possess an E6 ORF. The E6 oncoprotein of human papillomavirus (HPV) binds and degrades the tumour suppressor protein p53, thus contributing to tumour progression. Since BPV-4 lacks E6, it is unknown how the virus evades the tumour suppressor propertie...
Topics
- Animals
- Bovine papillomavirus 1
- Bovine papillomavirus 4
- Cattle
- Cell Line
- Cell Transformation, Viral
- Fibroblasts
- Genome, Viral
- Humans
- Mice
- Mutation
- Oncogene Proteins, Viral
- Open Reading Frames
- Repressor Proteins
- Tumor Suppressor Protein p53