Article
The platelet-derived growth factor beta receptor as a target of the bovine papillomavirus E5 protein.
Cytokine & growth factor reviews - 1 Dec 2000
DiMaio D, Lai C C, Mattoon D
Abstract excerpt
The 44-amino acid E5 protein of bovine papillomavirus is a homo-dimeric, transmembrane protein that transforms cells by activating the platelet-derived growth factor ss receptor in a ligand-independent fashion. The E5 protein induces receptor activation by forming a stable complex with the receptor, thereby inducing receptor dimerization, trans-phosphorylation of tyrosine residues in the cytoplasmic domain of the...
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