Molecular examination of the transmembrane requirements of the platelet-derived growth factor beta receptor for a productive interaction with the bovine papillomavirus E5 oncoprotein.

doi:10.1074/jbc.M209582200

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Article

Molecular examination of the transmembrane requirements of the platelet-derived growth factor beta receptor for a productive interaction with the bovine papillomavirus E5 oncoprotein.

The Journal of biological chemistry - 6 Dec 2002

Nappi Valerie M, Schaefer Julia A, Petti Lisa M

Abstract excerpt

The small transmembrane E5 protein of bovine papillomavirus (BPV) transforms cells by forming a stable complex with and activating the platelet-derived growth factor beta receptor (PDGFbetaR). The E5/PDGFbetaR interaction is thought to involve specific physical contacts between the transmembrane domains of the two proteins. Lys(499) at the extracellular juxtamembrane position and Thr(513) within the transmembrane...

Topics

Amino Acid Sequence
Amino Acids
Animals
Cell Line
Cell Membrane
Immunoblotting
Interleukin-3
Isoleucine
Lysine
Mice
Molecular Sequence Data

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Mutagenesis, Site-Directed

Mutation

Oncogene Proteins, Viral

Precipitin Tests

Protein Binding

Protein Structure, Tertiary

Receptor, Platelet-Derived Growth Factor beta

Source

Open in PubMed

Identifiers

PMID: 12351659
DOI: 10.1074/jbc.M209582200

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