Expression of activated mutants of the human interleukin-3/interleukin-5/granulocyte-macrophage colony-stimulating factor receptor common beta subunit in primary hematopoietic cells induces factor-independent proliferation and differentiation.

Abstract excerpt

To date, several activating mutations have been discovered in the common signal-transducing subunit (h(beta)c) of the receptors for human granulocyte-macrophage colony-stimulating factor, interleukin-3, and interleukin-5. Two of these, FIdelta and I374N, result in a 37 amino acid duplication and a single amino acid substitution in the extracellular domain of h(beta)c, respectively. A third, V449E, results in a...

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