Article
A mutation of the common receptor subunit for interleukin-3 (IL-3), granulocyte-macrophage colony-stimulating factor, and IL-5 that leads to ligand independence and tumorigenicity.
Blood - 15 May 1994
D'Andrea R, Rayner J, Moretti P, Lopez A, Goodall G J, Gonda T J, Vadas M
Abstract excerpt
The cytokines interleukin-3, interleukin-5, and granulocyte-macrophage colony-stimulating factor bind with high affinity to a receptor complex that contains a ligand-specific alpha-chain and a common beta-chain, h beta c. We report here the isolation of a mutant form of h beta c, from growth fact...
Topics
- Amino Acid Sequence
- Animals
- Base Sequence
- Granulocyte-Macrophage Colony-Stimulating Factor
- Humans
- Interleukin-3
- Interleukin-5
- Male
- Mice
- Mice, Inbred DBA
- Molecular Sequence Data
- Mutation
- Receptors, Granulocyte-Macrophage Colony-Stimulating Factor
- Receptors, Interleukin